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April 1, 1964Experimental Biology and Medicine

Enterovirus Typing by Complement Fixation

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Key result

Complement-fixation tests show ~96% agreement with viral neutralization tests in identifying enteroviruses.

Why the study?

The accuracy of complement-fixation tests for typing enteroviruses compared to viral neutralization tests was evaluated.

Does complement-fixation testing agree with viral neutralization tests in identifying enteroviruses?

Population

148 enteroviruses isolated by monkey kidney tissue culture

Comparison

Complement-fixation tests vs viral neutralization tests

Design

Diagnostic accuracy study

Authors

GGGladys M. GneshNew York State Department of HealthHPH. PlagerNew York State Department of HealthWDW DecherNew York State Department of Health

Discussion

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Member takes

Implication

May enable simpler enterovirus typing in labs; leaves open prospective clinical validation.

Structured PICO

Does complement-fixation testing agree with viral neutralization tests in identifying enteroviruses?

P
Population
148 enteroviruses isolated by monkey kidney tissue culture
I
Intervention
Complement-fixation tests using pooled and individual anti-sera of poliomyelitis Types I-III, ECHO Types 1-25, and Coxsackie Groups A Type 9, and B Types 1-5
C
Comparator
Viral neutralization tests
O
Outcome
Agreement in identifying enterovirusessurrogate

Complement-fixation tests are highly concordant with viral neutralization tests for typing enteroviruses.

Cite This Study

Gnesh et al. (1964) studied this question. Complement-fixation tests agreed with viral neutralization tests in identifying 142 (95.9%) of 148 enteroviruses isolated by monkey kidney tissue culture.

synapsesocial.com/papers/6aaa2f842cb60ec273f6c216https://doi.org/10.3181/00379727-115-29071
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A novel approach to enterovirus typing1991 · 5 citations
  2. 2Typing of Viruses by Combinations of Antiserum Pools. Application to Typing of Enteroviruses (Coxsackie and Echo)1960 · 204 citations
  3. 3Enterovirus typing by immune electronmicroscopy1996 · 9 citations
  4. 4Molecular Identification and Typing of Enteroviruses Isolated from Clinical Specimens2002 · 27 citations
  5. 5Identification of Enteroviruses by Hemagglutination-Inhibition1966 · 3 citations