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March 1, 1960The Journal of ImmunologyOpen Access

Typing of Viruses by Combinations of Antiserum Pools. Application to Typing of Enteroviruses (Coxsackie and Echo)

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Why the study?

Does the use of combination antiserum pools allow for specific typing of enteroviruses?

Population

24 enteroviruses (18 ECHO and 6 Coxsackie) and new virus isolates

Comparison

Typing using combination pools of antisera vs Individual tests of a virus antigen against an…

Design

Preclinical

Authors

ALApiradee LimPrince of Songkla UniversityMBMatilda Benyésh-MelnickWorld Health Organization - Pakistan

Discussion

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Implication

Pooled antisera enable specific enterovirus typing in animal models; leaves open clinical translation pending human validation.

Structured PICO

Does the use of combination antiserum pools allow for specific typing of enteroviruses?

P
Population
24 enteroviruses (18 ECHO and 6 Coxsackie) and new virus isolates
I
Intervention
Typing using combination pools of antisera (seven pools)
C
Comparator
Individual tests of a virus antigen against an array of typing sera
O
Outcome
Specific identification/typing of the virus isolatessurrogate

The use of combination antiserum pools provides an efficient and specific method for typing enteroviruses.

Cite This Study

Lim et al. (1960) studied this question.

synapsesocial.com/papers/6a715ab984cc45bb7bdfee1ehttps://doi.org/10.4049/jimmunol.84.3.309
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Enterovirus Typing by Complement Fixation1964 · 5 citations
  2. 2A novel approach to enterovirus typing1991 · 5 citations
  3. 3Counter-electrophoresis as a possible method for typing ECHO and Coxsackie B viruses.1975 · 10 citations
  4. 4An investigation of experimental factors affecting the identification of enteroviruses by immunoelectron microscopy1978
  5. 5Coxsackievirus B1-based antibody-capture enzyme-linked immunosorbent assay for detection of immunoglobulin G (IgG), IgM, and IgA with broad specificity for enteroviruses1993 · 40 citations