The preparation of lyophilized equine antisera pools simplifies the identification of 19 Group A Coxsackievirus serotypes in field isolates.
May streamline coxsackievirus A serotyping in isolates; leaves open validation for routine clinical and research use.
This paper describes the preparation of seven combination pools of equine antisera, designated J though P, for identification of 19 coxsackievirus A immunotypes. Each pool is composed of 4 to 6 antisera; the serotypes included are A1-6, 8, 10-15, and 17-22. These pools, unlike the previously prepared A-H enterovirus pools, were lyophilized from volumes of 0.5 ml dispensed into 5-ml vials, and when rehydrated with 5 ml of diluent provide 50-antibody-unit material ready for use in identification tests without further dilution. Procedures for using the antiserum pools are given, and guidance is provided for interpreting the results of serum neutralization tests in identifying field isolates.
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Melnick et al. (1977) studied this question.
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