The use of composite antiserum pools provides a practical, time-saving, and economical method for typing enteroviruses in tissue culture.
May enable economical enterovirus screening in tissue culture; leaves open clinical translation pending human validation.
A scheme is described for the identification of enteroviruses in tissue culture by neutralization with composite antiserum pools. The method for making these pools is given. Antisera to twenty-seven enteroviruses were included in the pools which were used to examine 115 viruses consisting of ninety-eight recently isolated viruses and seventeen prototype strains. The results indicate that this scheme provides a useful screening method for identifying enteroviruses. It has proved to be practicable, time saving and very economical in tissue culture. We are grateful to Dr C. M. P. Bradstreet who made available some of the rabbit antisera.
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Hambling et al. (1963) studied this question.
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