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August 1, 1978Proceedings annual meeting Electron Microscopy Society of America

An investigation of experimental factors affecting the identification of enteroviruses by immunoelectron microscopy

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Population

Enteroviruses (coxsackie, polio, echo)

Design

Preclinical

Authors

FLF. K. LeeNAN. AndersonIowa Academy of ScienceFDFrances W. DoaneUniversity of Toronto

Discussion

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Implication

Requires antiserum dilution optimization to minimize cross-reactivity; leaves open validation for clinical immunoelectron microscopy serotyping.

Structured PICO

P
Population
Enteroviruses (coxsackie, polio, echo)
I
Intervention
Immunoelectron microscopy (IEM) for serotyping enteroviruses, specifically testing the effect of antiserum concentration
O
Outcome
Presence of virus-antibody aggregates (cross-reactivity vs serotype specificity)surrogate

Antiserum concentration is a critical factor in avoiding cross-reactivity when serotyping enteroviruses using immunoelectron microscopy.

Cite This Study

Lee et al. (1978) studied this question.

synapsesocial.com/papers/6a86f31d3d239a2773cf8182https://doi.org/10.1017/s0424820100082674
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Specific identification of enteroviruses by immuno-electron microscopy using a serum-in-agar diffusion method1973 · 57 citations
  2. 2Serological cross-reactivity within the picornaviruses as studied by electron microscopy1971 · 14 citations
  3. 3Agar Diffusion Method for Negative Staining of Microbial Suspensions in Salt Solutions1972 · 39 citations
  4. 4Rapid detection of Australia/SH antigen and antibody by a simple and sensitive technique of immunoelectronmicroscopy1971 · 63 citations