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May 1, 1977Journal of Medical Microbiology

Picornaviruses: Rapid Differentiation and Identification by Immune Electronmicroscopy and Immunodiffusion

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Population

Human sera (n=21) and picornaviruses (seven human, six animal)

Comparison

Immune electronmicroscopy and immunodiffusion vs Control animal picornavirus

Design

Preclinical

Authors

JHJohn H. HughesThe Ohio State UniversityJGJohn M. GnauMHMilo D. HiltyNationwide Children's Hospital

Discussion

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Implication

Supports IEM for picornavirus antigen detection in research; leaves open clinical diagnostic translation.

Structured PICO

P
Population
Human sera (n=21) and picornaviruses (seven human, six animal)
I
Intervention
Immune electronmicroscopy (IEM) and immunodiffusion (ID)
C
Comparator
Control animal picornavirus
O
Outcome
Detection and differentiation of picornavirus C-type antigens

Immune electronmicroscopy is a sensitive and simple technique for detecting picornavirus C-type antigens and differentiating enteroviruses from rhinoviruses.

Cite This Study

Hughes et al. (1977) studied this question.

synapsesocial.com/papers/6a86f31d3d239a2773cf8183https://doi.org/10.1099/00222615-10-2-203
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Method for Testing Virus Stocks for Viral Contaminants1969 · 15 citations
  2. 2Plaque Formation by Rhinoviruses1968 · 10 citations
  3. 3Serological cross-reactivity within the picornaviruses as studied by electron microscopy1971 · 14 citations
  4. 4Specific identification of enteroviruses by immuno-electron microscopy using a serum-in-agar diffusion method1973 · 57 citations