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April 1, 1971Canadian Journal of Microbiology

Serological cross-reactivity within the picornaviruses as studied by electron microscopy

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Population

Picornavirus antigens and adenovirus type 7

Comparison

Treatment with poliovirus type 3 and echovirus… vs Controls

Design

Preclinical

Authors

RCRajesh ChaudharyBaidya and Banskota HospitalDKDana A. KennedyPfizer (United States)JWJ. C. N. WestwoodUniversity College Hospital

Discussion

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Implication

Indicates picornavirus antigenic overlap in animals; leaves open human diagnostic or immunologic relevance.

Structured PICO

P
Population
Picornavirus antigens (poliovirus type 1 and 3, echovirus type 9, and coxsackievirus type A9) and adenovirus type 7
I
Intervention
Treatment with poliovirus type 3 and echovirus type 9 antisera
C
Comparator
Controls (no antisera or adenovirus type 7 treated with antisera)
O
Outcome
Clumping of homologous and heterologous viruses observed via electron microscopysurrogate

Electron microscopy demonstrates serological cross-reactivity among different picornaviruses.

Cite This Study

Chaudhary et al. (1971) studied this question.

synapsesocial.com/papers/6a87f1f16fbb9257d814b241https://doi.org/10.1139/m71-079
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Detection of cross-reactions by immunofluorescence within the picornavirus group1970 · 5 citations
  2. 2Picornaviruses: Rapid Differentiation and Identification by Immune Electronmicroscopy and Immunodiffusion1977 · 15 citations
  3. 3Peptide antisera targeted to a conserved sequence in poliovirus capsid VP1 cross-react widely with members of the genus Enterovirus1993 · 89 citations
  4. 4Cross-reactions of immunoglobulin M and G antibodies with enterovirus-specific viral structural proteins1985 · 12 citations
  5. 5An investigation of experimental factors affecting the identification of enteroviruses by immunoelectron microscopy1978