May 1, 1994Clinical and Diagnostic Laboratory ImmunologyOpen Access

Molecular basis for serological cross-reactivity between enteroviruses

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Population

58 patients with culture-confirmed enteroviral infections

Design

Other

Authors

ASAgneta SamuelsonIthaka Harbors MFMarianne ForsgrenKarolinska University Hospital BJB JohanssonKarolinska University Hospital

Discussion

Member takes

Implication

May inform enterovirus serodiagnostic specificity; extends mapping of conserved cross-reactive VP1 epitopes.

Structured PICO

Population

58 patients with culture-confirmed enteroviral infections

Intervention

Enzyme immunoassays against overlapping synthetic peptides covering residues 31 to 96 of poliovirus 1 VP1 and residues 31 to 148 of coxsackievirus B1 VP1, and peptide analogs with sequential substitutions

Outcome

Recognition sites for human antibodies which are cross-reactive between different types of enterovirusessurrogate

The study identifies specific conserved residues within the enterovirus family that provide a molecular basis for serological cross-reactivity.

Cite This Study

Samuelson et al. (1994) studied this question.

synapsesocial.com/papers/69d56ec075589c71d767d5d4 https://doi.org/10.1128/cdli.1.3.336-341.1994

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Molecular basis for serological cross-reactivity between enteroviruses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Molecular basis for serological cross-reactivity between enteroviruses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider