September 1, 1996Journal of General Virology

A Study of the Cellular Immune Response to Enteroviruses in Humans: Identification of Cross-reactive T Cell Epitopes on the Structural Proteins of Enteroviruses

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Population

Peripheral blood mononuclear cells (PBMC) from healthy human donors

Design

Preclinical

Authors

JCJerónimo CelloStony Brook University ÖSÖ. StrannegårdPalo Alto University BSBo SvennerholmUniversity of Gothenburg

Discussion

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Implication

Hypothesis-generating for enteroviral T-cell vaccines targeting VP2/VP3; clinical relevance in humans remains to be tested.

Structured PICO

Population

Peripheral blood mononuclear cells (PBMC) from healthy human donors

Intervention

In vitro stimulation with six different serotypes of enterovirus and 15 synthetic peptides representing conserved regions in the four structural proteins of these viruses

Outcome

T cell proliferation and production of interferon-gamma (IFN-gamma), interleukin-4 (IL-4), and interleukin-10 (IL-10)surrogate

Human T cells recognize enteroviral cross-reactive epitopes primarily on capsid proteins VP2 and VP3, mediating a Th1-type immune response.

Cite This Study

Cello et al. (1996) studied this question.

synapsesocial.com/papers/6a84ff9d87b4268e825b60ff https://doi.org/10.1099/0022-1317-77-9-2097

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A Study of the Cellular Immune Response to Enteroviruses in Humans: Identification of Cross-reactive T Cell Epitopes on the Structural Proteins of Enteroviruses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Study of the Cellular Immune Response to Enteroviruses in Humans: Identification of Cross-reactive T Cell Epitopes on the Structural Proteins of Enteroviruses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider