Key result
Termination of long-term anticoagulant therapy in patients with chronic coronary heart disease induced a significant increase in platelet procoagulant activity.
Why the study?
Does the termination of long-term anticoagulant therapy affect platelet function in patients with chronic coronary heart disease?
Population
59 patients with chronic coronary heart disease clinically stabilized after more than 1 year of an acute…
Comparison
Termination of long-term anticoagulant therapy… vs Patients while on long-term ACT and a control…
Design
Cohort
Follow-up
within 2 months after termination
Authors
Loading...
Persistent platelet activation in stable post-MI patients persists regardless of anticoagulation; leaves open whether adjunctive antiplatelet strategies improve outcomes.
Observational (n=59)
Does the termination of long-term anticoagulant therapy affect platelet function in patients with chronic coronary heart disease?
Termination of long-term anticoagulant therapy in patients with chronic coronary heart disease induces an increase in platelet function, suggesting a potential rebound hypercoagulable state.
Vallés et al. (2009) conducted an observational in Chronic coronary heart disease (n=59). Termination of long-term anticoagulant therapy (acenocoumarol) vs. Control group and baseline (on therapy) was evaluated on Platelet function (plasma beta-thromboglobulin, platelet procoagulant activity, and malondialdehyde). Termination of long-term anticoagulant therapy in patients with chronic coronary heart disease induced a significant increase in platelet procoagulant activity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: