Decrease of sympathetic cardiovascular modulation after temporal lobe epilepsy surgery
Key result
Temporal lobe epilepsy surgery significantly reduced low frequency powers of heart rate and systolic blood pressure, as well as baroreflex sensitivity, compared to pre-surgical baseline (P < 0.05).
Why the study?
Does TLE surgery reduce sympathetic cardiovascular modulation in patients with temporal lobe epilepsy?
Population
18 patients with temporal lobe epilepsy (TLE)
Comparison
Temporal lobe epilepsy (TLE) surgery vs Pre-surgical baseline (3-4 months before surgery)
Design
Cohort
Follow-up
3-4 months after surgery
Authors
Discussion
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Member takes
Implication
TLE surgery effects on BRS unstudied until now; leaves open whether autonomic control improves postoperatively.
Study Design
Type
Observational (n=18)
Structured PICO
Does TLE surgery reduce sympathetic cardiovascular modulation in patients with temporal lobe epilepsy?
P
Population
18 patients with temporal lobe epilepsy evaluated 3-4 months before and after TLE surgery.
E
Exposure
Temporal lobe epilepsy (TLE) surgery
C
Comparator
Pre-surgical baseline (3-4 months before surgery)
O
Outcome
Sympathetic and parasympathetic modulation assessed by spectral analysis of HR and BPsys oscillations, and baroreflex sensitivity (BRS)surrogate
Main Result
p-value: p=< 0.05
TLE surgery reduces sympathetic cardiovascular modulation and baroreflex sensitivity, which may help stabilize cardiovascular control and reduce the risk of sudden unexpected death in epilepsy (SUDEP).
Cite This Study
Hilz et al. (2002) conducted an observational in Temporal lobe epilepsy (TLE) (n=18). Temporal lobe epilepsy (TLE) surgery vs. Pre-surgical baseline was evaluated on Sympathetic and parasympathetic modulation (LF and HF powers of HR and BPsys) and baroreflex sensitivity (BRS) (p=< 0.05). Temporal lobe epilepsy surgery significantly reduced low frequency powers of heart rate and systolic blood pressure, as well as baroreflex sensitivity, compared to pre-surgical baseline (P < 0.05).