Key result
Complex formation with cTnI decreases interdomain flexibility and maintains cardiac troponin C in an extended conformation.
Population
Recombinant cardiac troponin C (cTnC) and troponin I (cTnI) proteins
Comparison
Complex formation with recombinant troponin I… vs Free cardiac troponin C (cTnC) monomer
Design
Preclinical
Authors
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Maps cTnC conformational shifts in troponin complexes; extends structural models but leaves open clinical translation.
Binding of cardiac troponin I to cardiac troponin C decreases interdomain flexibility, maintaining cTnC in an extended conformation.
Kleerekoper et al. (1995) studied this question. Complex formation with recombinant troponin I proteins vs. Free cardiac troponin C (cTnC) was evaluated on Conformational changes and interdomain flexibility. Complex formation with cTnI decreases interdomain flexibility and maintains cardiac troponin C in an extended conformation.
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