Key result
Isotonic saline expansion in rats lowered plasma ANG II levels to 30 pM (P<0.01) but did not significantly decrease intraluminal ANG II, indicating independent regulation.
Population
Rats (preclinical model)
Comparison
Measurement of proximal tubular fluid… vs Plasma ANG II concentrations; presence vs…
Design
Preclinical
Authors
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Intrarenal ANG II secretion may modulate tubular sodium handling; leaves open compartmental RAS targeting in hypertension and HF.
Absolute Event Rate: 30% vs 155%
p-value: p=< 0.01
The proximal tubule secretes substantial amounts of angiotensin II into the tubular lumen, maintaining nanomolar concentrations that are regulated independently of plasma levels.
Braam et al. (1993) studied this question. Isotonic saline expansion vs. Baseline was evaluated on Plasma ANG II levels (pM) (p=< 0.01). Isotonic saline expansion in rats lowered plasma ANG II levels to 30 pM (P<0.01) but did not significantly decrease intraluminal ANG II, indicating independent regulation.
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