Endogenous production of angiotensin II modulates rat proximal tubule transport.
Population
male Sprague-Dawley rats
Comparison
Luminal perfusion of Dup 753 or enalaprilat with… vs Control (baseline fluid reabsorption)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Endogenous tubular angiotensin II modulates proximal reabsorption independently; leaves open translation to human natriuresis or therapy.
Structured PICO
P
Population
male Sprague-Dawley rats
I
Intervention
Luminal perfusion of Dup 753 (10^-8 M) or enalaprilat (10^-4 M) with or without exogenous angiotensin II
C
Comparator
Control (baseline fluid reabsorption)
O
Outcome
Rate of fluid reabsorption in the proximal tubulesurrogate
Endogenously produced angiotensin II modulates fluid transport in the proximal tubule independent of systemic angiotensin II.
Cite This Study
Quan et al. (1996) studied this question.