Key result
Exposure of rabbit Purkinje fibers to hypoxia and lactic acidosis increased action potential duration during recovery by up to 241.0 msec (p<0.005), precipitating early afterdepolarizations.
Why the study?
Does acidosis combined with hypoxia induce early afterdepolarizations and triggered activity in rabbit Purkinje fibers during recovery?
Does acidosis combined with hypoxia induce early afterdepolarizations and triggered activity in rabbit Purkinje fibers during recovery?
p-value: p=<0.005
Acidosis during ischemia, combined with slow pacing frequencies, may mediate early afterdepolarizations and triggered activity during reperfusion, potentially contributing to reperfusion arrhythmias.
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Suggests cycle length modulates triggered activity in reperfusion; leaves open relevance to clinical arrhythmias.
Rozanski et al. (1991) studied Ischemic-like conditions. Hypoxia plus lactic acidosis vs. Control (hypoxia alone, pH 7.4) was evaluated on Action potential duration (90% repolarization) during recovery (p=<0.005). Exposure of rabbit Purkinje fibers to hypoxia and lactic acidosis increased action potential duration during recovery by up to 241.0 msec (p<0.005), precipitating early afterdepolarizations.
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