Studies on the Elimination of Exogenous Lipids from the Blood Stream The Kinetics of the Elimination of a Fat Emulsion Studied by Single Injection Technique in Man

Hallberg, D. Studies on the elimination of exogenous lipids from the blood stream. The kinetics of the elimination of a fat emulsion studied by single injection technique in man. Acta physiol. scand. 1965. 64 , 306–313. – The kinetics of the elimination of a fat emulsion (Intralipid®) from the blood stream was studied after single injections to 10 fasting individuals. Plasma triglycerides (TG) were fractionated by means of polyvinylpyrrolidone density gradients into three fractions. The emulsion TG was found in the top fraction of the gradient and endogenous plasma TG separated into two fractions which were found in the lower part of the density gradient. The kinetics of the emulsion TG fraction were composed of a zero order elimination rate at high TG concentrations and a first order elimination rate at low TG concentrations. Intra‐individual variations were only observed in the zero order part of the kinetics; the possible causes of these variations are discussed. Changes in concentration of the lipids found in the lower part of the density gradient were observed during the elimination of the emulsion TG from the circulation. The possibility that the kinetic principle for one of these fractions (middle fraction) is the same as that for the fat emulsion is discussed.