Key result
ST-segment resolution at 24 to 36 hours after fibrinolysis was inversely correlated with 1-year mortality (r=-0.963, P<0.001), and treatment <2 hours further reduced mortality across all categories.
Why the study?
Does time to treatment influence ST-segment resolution at 24 to 36 hours and 1-year mortality in patients with acute myocardial infarction receiving fibrinolysis?
Cohort (n=13,100)
Does time to treatment influence ST-segment resolution at 24 to 36 hours and 1-year mortality in patients with acute myocardial infarction receiving fibrinolysis?
Effect estimate: r=-0.963
p-value: p=<0.001
Time to treatment with fibrinolysis in acute myocardial infarction strongly influences ST-segment resolution at 24-36 hours, which is inversely correlated with 1-year mortality, highlighting the critical importance of minimizing treatment delays.
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Early MI treatment linked to better ST resolution and survival; leaves open causal role of time windows in prognostic data.
Fu et al. (2001) conducted a cohort in acute myocardial infarction (n=13,100). ST-segment resolution and time to treatment vs. Lower ST resolution or longer time to treatment was evaluated on 1-year mortality (r=-0.963, p=<0.001). ST-segment resolution at 24 to 36 hours after fibrinolysis was inversely correlated with 1-year mortality (r=-0.963, P<0.001), and treatment <2 hours further reduced mortality across all categories.
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