Key result
Osteopontin, collagen type I, and collagen type III mRNA levels were significantly higher in patients with dilated cardiomyopathy compared to controls (P<0.01).
Population
51 patients with dilated cardiomyopathy and 15 controls undergoing right ventricular endomyocardial biopsy
Design
Case-control
Authors
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Hypothesis-generating for osteopontin as fibrosis target in DCM; should not yet change practice.
Case-Control (n=66)
p-value: p=<0.01
Myocardial osteopontin expression is elevated in human dilated cardiomyopathy and correlates with collagen accumulation and reduced left ventricular ejection fraction, suggesting a role in cardiac fibrosis.
Satoh et al. (2005) conducted a case-control in Dilated cardiomyopathy (n=66). Dilated cardiomyopathy vs. Controls was evaluated on Osteopontin (OPN), collagen type I, and collagen type III mRNA levels (p=<0.01). Osteopontin, collagen type I, and collagen type III mRNA levels were significantly higher in patients with dilated cardiomyopathy compared to controls (P<0.01).
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