Key result
Higher osteopontin plasma levels significantly correlated with lower left ventricular mass regression 3 months after surgical aortic valve replacement.
Why the study?
The study evaluated the prognostic value of osteopontin as a marker for left ventricular hypertrophy and its reversibility after surgical aortic valve replacement.
Do osteopontin plasma levels predict left ventricular mass regression after surgical aortic valve replacement?
Cohort (n=149)
Do osteopontin plasma levels predict left ventricular mass regression after surgical aortic valve replacement?
Osteopontin plasma levels may serve as a useful biomarker to predict the reversibility of left ventricular hypertrophy following surgical aortic valve replacement.
OPN may mark reversible LV hypertrophy after SAVR; hypothesis-generating and needs prospective validation before clinical use.
Aim: The aim of this study was to evaluate the prognostic value of osteopontin (OPN) as a marker for left ventricular (LV) hypertrophy and its reversibility after surgical aortic valve replacement (SAVR). Patients & methods: Echocardiographic data and OPN plasma levels of 149 consecutive patients undergoing SAVR were obtained preoperatively and 3 months postoperatively. OPN was measured by Quantikine Human OPN immunoassay. Results: There was a significant correlation between higher OPN plasma levels and lower LV-mass regression. In patients receiving SAVR combined with coronary artery bypass grafting, high OPN plasma levels were also an indicator for eccentric hypertrophy phenotype. Conclusion: OPN may be a useful indicator for LV hypertrophy phenotype and could have a prognostic value to estimate LV-mass regression after SAVR.
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Weber et al. (2020) conducted a cohort in Left ventricular hypertrophy (n=149). Osteopontin (OPN) plasma levels was evaluated on Left ventricular mass regression. Higher osteopontin plasma levels significantly correlated with lower left ventricular mass regression 3 months after surgical aortic valve replacement.
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