Key result
Ischemic preconditioning significantly reduced infarct size in rabbit hearts (4.7% vs 26.6%, P<0.0001), but this protection was abolished by chloride channel inhibitors IAA-94 or NPPB.
Population
Isolated rabbit ventricular myocytes and buffer-perfused rabbit hearts
Comparison
Chloride channel inhibitors administered before… vs Control or ischemic preconditioning with vehicle
Design
Preclinical
Authors
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Cl− channel blockade may blunt IP in isolated myocytes; leaves open in vivo or clinical relevance.
Absolute Event Rate: 4.7% vs 26.6%
p-value: p=<0.0001
Chloride channels play a critical role in the myocardial protection afforded by ischemic preconditioning against ischemia/reperfusion injury in a rabbit model.
Diaz et al. (1999) studied Ischemic/reperfusion injury. Chloride channel inhibitors (IAA-94 or NPPB) during ischemic preconditioning vs. Control (no preconditioning) and IP + vehicle was evaluated on Infarct size (p=<0.0001). Ischemic preconditioning significantly reduced infarct size in rabbit hearts (4.7% vs 26.6%, P<0.0001), but this protection was abolished by chloride channel inhibitors IAA-94 or NPPB.
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