Population
Rabbit ventricular myocytes
Comparison
Swelling in solutions with 0.6-0.9x normal… vs Isotonic or hypertonic media, or unblocked state
Design
Preclinical
Authors
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Animal swelling data should not alter practice; leaves open cation current roles in human myocyte volume and electrophysiology.
Both cation and anion swelling-activated currents modulate the volume of ventricular myocytes, with ICir,swell likely contributing to diastolic depolarization and affecting contraction.
Clemo et al. (1997) studied this question.
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