Key result
Hyposmotic challenge in chick cardiac myocytes induces a transient current necessary for regulatory volume decrease.
A transient swelling-induced current (I(swell)) is a necessary prerequisite for regulatory volume decrease in embryonic chick cardiac myocytes following hyposmotic swelling.
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Should not change clinical volume management; leaves open whether I(swell)-like currents mediate regulatory volume decrease in mammalian cardiomyocytes.
Hall et al. (1997) studied Embryonic chick cardiac myocytes. Hyposmotic challenge vs. Control values was evaluated on Changes in membrane conductance and cell volume. Hyposmotic challenge in embryonic chick cardiac myocytes induced a rapid, transient current (I(swell)) that was necessary for subsequent regulatory volume decrease.
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