Key result
In isolated guinea pig ventricular myocytes, swelling-activated chloride current (ICl,swell) regulates cell volume, inducing either regulatory volume decrease or extra cell inflation depending on the membrane and chloride equilibrium potentials.
Population
Ventricular myocytes isolated from guinea pigs (250–400 g body weight)
Comparison
Application of hyposmotic and isosmotic… vs Control solutions without inhibitors or under…
Design
Preclinical
Authors
Loading...
ICl,swell modulation of myocyte volume should not change practice; leaves open its role in human cardiac edema or ischemia.
Swelling-activated chloride currents regulate cardiac cell volume by inducing shrinkage or inflation depending on the membrane potential and chloride equilibrium potential.
Yamamoto et al. (2004) studied Cell-volume regulation in ventricular myocytes. ICl,swell inhibitors (DIDS, glibenclamide, furosemide) and osmotic challenges vs. Drug-free control solutions was evaluated on Change in relative cell area (volume). In isolated guinea pig ventricular myocytes, swelling-activated chloride current (ICl,swell) regulates cell volume, inducing either regulatory volume decrease or extra cell inflation depending on the membrane and chloride equilibrium potentials.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: