Population
Ventricular myocytes isolated from normal dogs and dogs with rapid ventricular pacing-induced congestive…
Comparison
Osmotic swelling/shrinkage and application of 10… vs Normal dog myocytes; isosmotic vs…
Design
Preclinical
Authors
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Hypothesis-generating for volume-sensitive currents in CHF; leaves open therapeutic relevance pending human myocyte studies.
Congestive heart failure alters the set point for and causes persistent activation of swelling-activated cation currents, which may contribute to dysrhythmias and altered contractile function.
Clemo et al. (1998) studied this question.
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