Key result
Epinephrine (1 µM) increased Ca2+ current and Ca2+ transients, accelerated their rate of decline, and reduced baseline intracellular Ca2+ at extreme potentials in rat ventricular myocytes.
Population
Isolated single rat ventricular myocytes
Comparison
Epinephrine, Ryanodine, and intracellular cAMP… vs Baseline/control conditions without the…
Design
Preclinical
Authors
Loading...
Enables precise Ca2+ transient measurements in isolated myocytes; leaves open translation to human cardiac function or therapy.
In rat ventricular myocytes, epinephrine enhances Ca2+ release by increasing Ca2+ current and accelerates Ca2+ reuptake via the adenylate cyclase system.
Callewaert et al. (1988) studied Healthy rat ventricular myocytes. Epinephrine vs. Control conditions (absence of epinephrine) was evaluated on Intracellular Ca2+ transients and Ca2+ current (ICa). Epinephrine (1 µM) increased Ca2+ current and Ca2+ transients, accelerated their rate of decline, and reduced baseline intracellular Ca2+ at extreme potentials in rat ventricular myocytes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: