What is the clinical evidence from this study?

Study design: Other. Population: Doxorubicin-induced liver toxicity. Intervention: Rutin and quercetin vs. Doxorubicin alone. Primary outcome: Liver injury markers (AST, ALT, ALP, bilirubin, albumin, AFP, CA 19.9, oxidative stress, apoptosis, Nrf2 expression).

January 1, 2022Oxidative Medicine and Cellular Longevity88 citationsOpen Access

Rutin and Quercetin Counter Doxorubicin‐Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2

OAOsama M. AhmedBeni-Suef University MEMohammed H. ElkomyJouf University HFHanaa I. FahimBeni-Suef University

Resultado clave

Rutin and quercetin, alone or in combination, significantly improved liver injury markers, oxidative stress, and histological changes in doxorubicin-injected male Wistar rats.

PICO estructurado

Do rutin and quercetin prevent doxorubicin-induced liver toxicity in male Wistar rats?

Población

Male Wistar rats treated with doxorubicin to induce liver toxicity, followed for 5 weeks.

Intervención

Rutin and quercetin (50 mg/kg) either alone or in combination orally every other day for five weeks concomitant with intraperitoneal doxorubicin

Comparador

Intraperitoneal doxorubicin (2 mg/kg) two times a week for five successive weeks

Resultado

Serum AST, ALT, and ALP activities, total bilirubin, albumin, AFP, and CA 19.9 levelssurrogate

Rutin and quercetin may have potential preventive effects against doxorubicin-induced hepatotoxicity through inhibiting oxidative stress, inflammation, and apoptosis.

Resumen

The presented study was performed to verify whether rutin and/or quercetin can inhibit liver injury induced by doxorubicin (DXR) in male Wistar rats. In this study, male Wistar rats were treated via the oral route with rutin and quercetin (50 mg/kg) either alone or in combination every other day for five weeks concomitant with receiving intraperitoneal DXR (2 mg/kg) two times a week for five successive weeks. Quercetin, rutin, and their combination significantly improved the deteriorated serum AST, ALT, and ALP activities and total bilirubin level, as well as albumin, AFP, and CA 19.9 levels in DXR‐injected rats. Treatments of the DXR‐injected group with quercetin and rutin prevented the elevation in liver lipid peroxidation and the reduction in superoxide dismutase, glutathione‐S‐transferase and glutathione peroxidase activities, and glutathione content. Treatments with quercetin and rutin significantly repressed the elevated expression of liver p53 and TNF‐ α and enhanced Nrf2 expression. Furthermore, the treatments significantly reduced DXR‐induced liver histological changes. In conclusion, rutin and quercetin either alone or in combination may have potential preventive effects against DXR‐induced hepatotoxicity through inhibiting oxidative stress, inflammation, and apoptosis as well as modulating the Nrf2 expression.

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