Key result
Regular exercise plus antihypertensive medication significantly reduced diastolic blood pressure (83 vs 90 mm Hg, P=0.002) and left ventricular mass at 16 weeks compared to medication alone.
Why the study?
Does regular moderately intense exercise reduce blood pressure and left ventricular hypertrophy in African-American men with severe hypertension?
Population
46 African-American men, 35 to 76 years of age, with severe hypertension
Comparison
Moderately intense exercise plus… vs Antihypertensive medication alone
Design
RCT, Randomly assigned
Follow-up
16 to 32 weeks
Authors
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May support exercise for severe hypertension control; leaves open LVH effects pending randomized trials.
RCT (n=46)
Randomly assigned
Does regular moderately intense exercise reduce blood pressure and left ventricular hypertrophy in African-American men with severe hypertension?
Absolute Event Rate: 83% vs 90%
p-value: p=0.002
Regular moderate exercise significantly reduces diastolic blood pressure and left ventricular hypertrophy in African-American men with severe hypertension, even allowing for reductions in antihypertensive medication.
Kokkinos et al. (1995) conducted an RCT in Severe hypertension (n=46). Regular exercise plus antihypertensive medication vs. Antihypertensive medication alone was evaluated on Diastolic blood pressure at 16 weeks (p=0.002). Regular exercise plus antihypertensive medication significantly reduced diastolic blood pressure (83 vs 90 mm Hg, P=0.002) and left ventricular mass at 16 weeks compared to medication alone.
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