Key result
HIV infection was associated with a higher prevalence of diastolic dysfunction compared to healthy controls (16.5% vs 7.2%, P<0.027), which did not significantly change after 48 weeks of ART.
Why the study?
Does HIV infection and subsequent ART initiation affect the prevalence of echocardiographic abnormalities in Chinese persons living with HIV?
Cohort (n=325)
Yes
Does HIV infection and subsequent ART initiation affect the prevalence of echocardiographic abnormalities in Chinese persons living with HIV?
Absolute Event Rate: 16.5% vs 7.2%
p-value: p=<0.027
HIV infection is associated with a higher prevalence of diastolic dysfunction, which does not significantly improve after 48 weeks of antiretroviral therapy.
May support echocardiographic screening in PLWH; leaves open long-term ART effects on progression.
BACKGROUND: Persons living with human immunodeficiency virus (HIV) are at increased risk of developing cardiovascular disease. Few studies have focused on echocardiographic abnormalities in this population. METHODS: China AIDS Clinical Trial 0810 is a prospective, multicenter cohort study of persons living with HIV (PLWH). We performed an echocardiography substudy of 325 PLWH. We examined the prevalence of left ventricular systolic dysfunction (LVSD), diastolic dysfunction (DD), pulmonary arterial hypertension (PAH), and increased left ventricular mass (ILVM) in antiretroviral therapy (ART)-naive PLWH at baseline and week 48 after initiation of ART. RESULTS: Compared with age- and sex-matched healthy controls, PLWH had a higher prevalence of DD (16.5% vs 7.2%, P < .027) and a marginally significant higher prevalence of LVSD (7.3% vs 2.1%, P = .056). The increase in the prevalence of DD from baseline to week 48 in PLWH was marginally significant (P = .056). No significant difference was observed in the prevalence of LVSD, PAH, or ILVM at baseline and week 48 in PLWH. In logistic regression analysis of all participants, age was significantly associated with LVSD; HIV infection, age, and hypertension were associated with DD whereas HIV infection and hypertension were associated with ILVM at baseline. Logistic regression analysis of PLWH showed that only age was significantly associated with LVSD and DD. CONCLUSIONS: The prevalence of echocardiographic abnormalities was significantly higher in ART-naive PLWH than in controls. HIV infection was significantly associated with cardiac abnormalities. No significant change in echocardiographic abnormalities was observed after 48 weeks of ART. Longer-term prospective studies are warranted.
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Luo et al. (2014) conducted a cohort in HIV infection (n=325). HIV infection vs. Age- and sex-matched healthy controls was evaluated on Diastolic dysfunction (DD) (p=<0.027). HIV infection was associated with a higher prevalence of diastolic dysfunction compared to healthy controls (16.5% vs 7.2%, P<0.027), which did not significantly change after 48 weeks of ART.
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