Key result
In young adults aged 18-40 with newly diagnosed heart failure, 61.3% presented with reduced ejection fraction, and myocarditis was the primary etiology associated with favorable outcomes.
Why the study?
Most heart failure studies have focused on older adults, leaving etiology and specific trends among young adults poorly understood.
Observational (n=80)
In young adults aged 18-40 with newly diagnosed heart failure, HFrEF due to myocarditis is the most common presentation and is associated with favorable outcomes compared to valvular etiologies.
May inform etiology-specific prognosis in young HF; leaves open need for prospective validation.
Background Although the diagnosis of heart failure (HF) in young adults is infrequent, it is not a rare and potentially fatal diagnosis. Most HF studies were based on older adults, and little is known about the etiology and specific trends in HF among this group. We can highlight and give support for such precious group through analysis of their specific predisposing factors, clinical presentation, imaging, angiographic findings and their outcomes. Aim Analysis of HF in the young. Patients and methods A total of 80 patients between the ages of 18–40 years old were enrolled with recent symptoms and signs of clinically evident HF and echocardiographic evidence of any type of HF, whatever the etiological diagnosis or mode of presentation. Results Most cases were overweight or obese, BMI (28.53 ± 3.17 kg/m 2 ), and smokers (38.8%). Most of cases were symptomatic, in-patient in NYHA class III or IV (40 and 45% respectively). Most of patients were from HF with reduced ejection fraction type (61.3%). At 3 months after initiation of GDMT, six patients had HF with improved ejection fraction. Myocarditis was the main aetiological diagnosis. Favorable clinical outcome was seen with Myocarditis and ischemic etiology; however, the worst outcome was related to valvular etiology, specifically infective pathology. Conclusion HF in young adults is uncommon, yet it is not rare, there are more cases than we expect.
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Mohamed et al. (2026) conducted an observational in Heart failure (n=80). Heart failure in young adults was evaluated. In young adults aged 18-40 with newly diagnosed heart failure, 61.3% presented with reduced ejection fraction, and myocarditis was the primary etiology associated with favorable outcomes.
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