Key result
Activated protein C resistance (Factor V Leiden) was associated with a 4.5-fold increased risk of deep vein thrombosis and a 3.2-fold increased risk of pulmonary embolism compared to healthy controls.
Why the study?
Activated protein C resistance due to factor V Leiden mutation is a major risk factor for venous thromboembolism, prompting investigation into symptom patterns and VTE risk across clinical, laboratory, and demographic properties.
Does Activated Protein C Resistance (Factor V Leiden) increase the risk of venous thromboembolism compared to healthy controls?
Cross-Sectional (n=576)
No
Does Activated Protein C Resistance (Factor V Leiden) increase the risk of venous thromboembolism compared to healthy controls?
Odds Ratio: 4.5
Absolute Event Rate: 39.2% vs 12.5%
p-value: p=<0.05
Activated Protein C Resistance (Factor V Leiden) is a significant independent risk factor for venous thromboembolism (DVT and PE), supporting the use of phenotypic testing in patients presenting with VTE.
No takes yet. Share an insight, caveat, or question.
APCR associated with higher DVT/PE risk in men but not AT or pregnancy issues; leaves open whether phenotypic screening alters VTE management.
Takhviji et al. (2021) conducted a cross-sectional in Activated Protein C Resistance (Factor V Leiden) / Venous Thromboembolism (n=576). Activated protein C resistance (Factor V Leiden) vs. Healthy controls without APCR was evaluated on Deep vein thrombosis (DVT) (OR 4.5, p=<0.05). Activated protein C resistance (Factor V Leiden) was associated with a 4.5-fold increased risk of deep vein thrombosis and a 3.2-fold increased risk of pulmonary embolism compared to healthy controls.