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November 1, 1996Blood Coagulation & Fibrinolysis

The influence of factor VIII on measurement of activated protein C resistance

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Population

Patients with activated protein C resistance who do not possess the FVQ506 polymorphism, and normal patient…

Design

Other

Authors

MLMichael LaffanOxford University Hospitals NHS TrustRMRichard A. ManningGuy's and St Thomas' NHS Foundation Trust

Discussion

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Implication

Does not support replacing functional APCR assays with genotyping alone; leaves open the role of FVIIIc testing in thrombophilia evaluation.

Structured PICO

P
Population
Patients with activated protein C resistance (APCR) who do not possess the FVQ506 (Factor V Leiden) polymorphism, and normal patient plasma.
I
Intervention
Measurement of FVIIIc levels, spiking experiments, and venous occlusion tests.
O
Outcome
APCR ratio and activated partial thromboplastin time (APTT)surrogate

Elevated Factor VIIIc levels can cause activated protein C resistance in the absence of the Factor V Leiden mutation, suggesting functional APCR tests should not be entirely replaced by DNA analysis.

Cite This Study

Laffan et al. (1996) studied this question.

synapsesocial.com/papers/6a6f78c3fe4101aa97dfcb43https://doi.org/10.1097/00001721-199611000-00003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Retrospective Cross-sectional Study on Activated Protein C Resistance (Factor V Leiden): an Independent, Gender-dependent Risk Factor for Venous Thromboembolism2021
  2. 2Activated Protein C Resistance and the FV:R506Q Mutation in a Random Population Sample1999 · 85 citations
  3. 3Activated Protein C Resistance Assay Detects Thrombotic Risk Factors Other Than Factor V Leiden2003 · 35 citations
  4. 4Activated Protein C Resistance Assay Detects Thrombotic Risk Factors Other Than Factor V Leiden2003 · 28 citations
  5. 5Improved Distinction of Factor V Wild-Type and Factor V Leiden Using a Novel Prothrombin-Based Activated Protein C Resistance Assay2004 · 30 citations