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January 1, 1999Thrombosis and Haemostasis

Activated Protein C Resistance and the FV:R506Q Mutation in a Random Population Sample

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Population

955 adults (460 men, 495 women) aged 25-74 years from a random population sample (Glasgow MONICA Survey)

Design

Cross-sectional

Authors

ARAnn RumleyPreventive CardiologyMWMark WoodwardUniversité Claude Bernard Lyon 1EREvan ReidNHS Greater Glasgow and Clyde

Discussion

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Implication

APC resistance may mark in vivo hypercoagulability; cross-sectional data leave open prospective thrombotic risk prediction.

Structured PICO

P
Population
955 adults (460 men, 495 women) aged 25-74 years from a random population sample (Glasgow MONICA Survey)
O
Outcome
Correlation of APC ratio with clinical and coagulation variablessurrogate

APC resistance is associated with elevated plasma levels of coagulation markers, suggesting it represents an in vivo hypercoagulable state influenced by age, sex, obesity, and factor VIIIc levels.

Cite This Study

Rumley et al. (1999) studied this question.

synapsesocial.com/papers/6a10e7be2c0ee39daeee4e0dhttps://doi.org/10.1055/s-0037-1614599

Topics

Women and heart disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Resistance to activated protein C and FV Leiden mutation in patients with a history of acute myocardial infarction or primary hypertension2000 · 24 citations
  2. 2The VITA Project: Phenotypic Resistance to Activated Protein C and FV Leiden Mutation in the General Population1997 · 36 citations
  3. 3Activated Protein C Resistance Assay Detects Thrombotic Risk Factors Other Than Factor V Leiden2003 · 28 citations
  4. 4Activated Protein C Resistance Assay Detects Thrombotic Risk Factors Other Than Factor V Leiden2003 · 35 citations
  5. 5No association of APC resistance with myocardial infarction1995 · 39 citations