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January 1, 2003American Journal of Clinical Pathology

Activated Protein C Resistance Assay Detects Thrombotic Risk Factors Other Than Factor V Leiden

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Key result

Measuring APC resistance without factor V-deficient plasma dilution detects thrombotic risks beyond factor V Leiden.

  • n=65

Why the study?

Does measurement of APC resistance without dilution in factor V-deficient plasma detect thrombotic risk factors other than Factor V Leiden?

Population

65 subjects in a blinded case-control study

Design

Case-control, blinded

Authors

LGLaurie L. GrafUniversity of Colorado DenverCWCarolyn H. WelshVA Eastern Colorado Health Care SystemZQZainab QamarAga Khan University

Discussion

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Implication

May detect additional thrombotic risks beyond FV Leiden; hypothesis-generating and should not yet change testing practice.

Study Design

Type

Case-Control (n=65)

Blinding

Blinded

Structured PICO

Does measurement of APC resistance without dilution in factor V-deficient plasma detect thrombotic risk factors other than Factor V Leiden?

P
Population
65 subjects in a blinded case-control study assessing mechanisms of activated protein C resistance.
E
Exposure
Measurement of activated protein C (APC) resistance using 3 methods: 2 activated partial thromboplastin time-based methods with and without dilution in factor V-deficient plasma and 1 Russell viper venom-based assay (RVV)
O
Outcome
Detection of APC resistance and identification of thrombotic risk factors other than Factor V Leidensurrogate

Measurement of APC resistance without dilution in factor V-deficient plasma can identify potentially important thrombotic risk factors beyond Factor V Leiden.

Cite This Study

Graf et al. (2003) conducted a case-control in Venous thromboembolism (n=65). Activated protein C (APC) resistance assay without dilution in factor V-deficient plasma vs. Assays with dilution in factor V-deficient plasma or RVV was evaluated on Detection of APC resistance. Measurement of APC resistance without dilution in factor V-deficient plasma identified 24 APC-resistant subjects, detecting thrombotic risk factors other than factor V Leiden.

synapsesocial.com/papers/6aa53ec950dab972bddd46b7https://doi.org/10.1309/qcuunrmvjy8mwppl
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of 3.2%<i>vs</i>3.8% Sodium Citrate Concentration on Routine Coagulation Testing1997 · 141 citations
  2. 2Actiated protein C resistance in the absence of factor V Leiden mutation is a common finding in multiple myeloma and is associated with an increased risk of thrombotic complications2002 · 137 citations
  3. 3A Factor V Genetic Component Differing From Factor V R506Q Contributes to the Activated Protein C Resistance Phenotype1997 · 212 citations
  4. 4Risk Factors in Venous Thromboembolism2001 · 298 citations
  5. 5Coinheritance of the HR2 Haplotype in the Factor V Gene Confers an Increased Risk of Venous Thromboembolism to Carriers of Factor V R506Q (Factor V Leiden)1999 · 114 citations