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January 1, 2003American Journal of Clinical Pathology

Activated Protein C Resistance Assay Detects Thrombotic Risk Factors Other Than Factor V Leiden

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Key result

Measuring APC resistance without dilution in factor V-deficient plasma identified 24 APC-resistant subjects, detecting potentially important thrombotic risk factors other than factor V Leiden.

Why the study?

Does measuring APC resistance without dilution in factor V-deficient plasma detect thrombotic risk factors other than Factor V Leiden?

Population

65 subjects in a blinded case-control study assessing venous thromboembolism risk factors

Comparison

Activated protein C resistance measurement… vs APC resistance measurement with dilution in…

Design

Case-control, blinded

Authors

ZQZainab QamarAga Khan UniversityCWCarolyn H. WelshVA Eastern Colorado Health Care SystemRMRichard A. MarlarUniversity of New Mexico

Discussion

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Implication

May identify non-FVL thrombotic risks; hypothesis-generating and requires validation before clinical adoption.

Study Design

Type

Case-Control (n=65)

Blinding

Blinded

Structured PICO

Does measuring APC resistance without dilution in factor V-deficient plasma detect thrombotic risk factors other than Factor V Leiden?

P
Population
65 subjects evaluated in a blinded case-control study to assess mechanisms contributing to activated protein C resistance beyond factor V Leiden.
E
Exposure
Activated protein C (APC) resistance measurement without dilution in factor V-deficient plasma
C
Comparator
APC resistance measurement with dilution in factor V-deficient plasma and Russell viper venom-based assay (RVV)
O
Outcome
Detection of APC resistance and underlying mechanisms (Factor V Leiden, elevated factor VIII, or other)surrogate

Measuring APC resistance without dilution in factor V-deficient plasma can identify potentially important thrombotic risk factors beyond Factor V Leiden.

Cite This Study

Qamar et al. (2003) conducted a case-control in Venous thromboembolism (VTE) and Activated protein C (APC) resistance (n=65). Activated protein C (APC) resistance assay without dilution in factor V-deficient plasma vs. Assays with dilution in factor V-deficient plasma or Russell viper venom-based assay was evaluated on Detection of APC resistance. Measuring APC resistance without dilution in factor V-deficient plasma identified 24 APC-resistant subjects, detecting potentially important thrombotic risk factors other than factor V Leiden.

synapsesocial.com/papers/6a973401473082e8a985fb43https://doi.org/10.1309/qcuu-nrmv-jy8m-wppl
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A prospective study of venous thromboembolism in relation to factor V Leiden and related factors2002 · 144 citations
  2. 2Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS)1989 · 2,517 citations
  3. 3Risk Factors in Venous Thromboembolism2001 · 298 citations
  4. 4A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study1991 · 1,975 citations
  5. 5A Factor V Genetic Component Differing From Factor V R506Q Contributes to the Activated Protein C Resistance Phenotype1997 · 212 citations