Key result
Inherited resistance to activated protein C was found in approximately 40% of consecutive thrombosis patients and is caused by a mutation in the factor V gene.
Population
Cohort of consecutive thrombosis patients, their families, and normal plasma
Design
Review
Authors
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May support factor V Leiden testing in venous thrombosis; leaves open standardized screening and management protocols.
Cohort
Inherited resistance to activated protein C, a major cause of venous thrombosis, is caused by a specific mutation in the factor V gene (Arg506Gln).
Björn Dahlbäck (2009) conducted a cohort in Venous Thrombosis. Activated protein C (APC) resistance was evaluated on Prevalence of APC-resistance. Inherited resistance to activated protein C was found in approximately 40% of consecutive thrombosis patients and is caused by a mutation in the factor V gene.
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