Why the study?
Does APC resistance increase the risk of VTE and adverse pregnancy outcomes in pregnant women?
Population
2,480 pregnant women enrolled in early pregnancy in Malmo, Sweden.
Comparison
Presence of Activated Protein C resistance vs Absence of APC resistance
Design
Cohort
Follow-up
until delivery (intrapartum)
Authors
Loading...
APC resistance may warrant VTE vigilance in pregnancy; leaves open whether testing or prophylaxis improves outcomes.
Does APC resistance increase the risk of VTE and adverse pregnancy outcomes in pregnant women?
APC resistance in pregnancy is associated with an 8-fold increased risk of VTE and reduced intrapartum blood loss, but not with other adverse pregnancy outcomes.
Lindqvist et al. (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: