Key result
A novel dual magnetic plethysmograph probe successfully measured local pulse wave velocity, demonstrating an average postexercise increment of 0.42 m/s and significant correlation with blood pressure.
Observational (n=20)
The novel dual MPG probe successfully measured local PWV, which increased post-exercise and correlated with blood pressure, suggesting potential for cuffless BP monitoring.
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Feasibility of dual-MPG probe for local PWV shown in phantoms and young adults; leaves open validation in patients before clinical use.
OBJECTIVE: We present the design and experimental validation of an arterial compliance probe with dual magnetic plethysmograph (MPG) transducers for local pulse wave velocity (PWV) measurement. The MPG transducers (positioned at 23 mm distance apart) utilizes Hall-effect sensors and permanent magnets for arterial blood pulse detection. METHODS: The MPG probe was initially validated on an arterial flow phantom using a reference method. Further, 20 normotensive subjects (14 males, age = 24 ± 3.5 years) were studied under two different physical conditions: 1) Physically relaxed condition, 2) Postexercise condition. Local PWV was measured from the left carotid artery using the MPG probe. Brachial blood pressure (BP) was measured to investigate the correlation of BP with local PWV. RESULTS: The proposed MPG arterial compliance probe was capable of detecting high-fidelity blood pulse waveforms. Reliable local pulse transit time estimates were assessed by the developed measurement system. Beat-by-beat local PWV was measured from multiple subjects under different physical conditions. A profound increment was observed in the carotid local PWV for all subjects after exercise (average increment = 0.42 ± 0.22 m/s). Local PWV values and brachial BP parameters were significantly correlated (r ≥ 0.72), except for pulse pressure (r = 0.42). CONCLUSION: MPG arterial compliance probe for local PWV measurement was validated. Carotid local PWV measurement, its variations due to physical exercise and correlation with BP levels were examined during the in vivo study. SIGNIFICANCE: A novel dual MPG probe for local PWV measurement and potential use in cuffless BP measurement.
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Nabeel et al. (2017) conducted an observational in Normotensive (n=20). Magnetic plethysmograph (MPG) probe vs. Reference method / Relaxed condition was evaluated on Carotid local pulse wave velocity (PWV) increment after exercise (average increment 0.42 m/s). A novel dual magnetic plethysmograph probe successfully measured local pulse wave velocity, demonstrating an average postexercise increment of 0.42 m/s and significant correlation with blood pressure.
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