Key result
Angiogenic gene programming and therapies that activate hypoxia inducible factor-1 may preserve the coronary microvasculature and maintain cardiac diastolic function in diastolic heart failure.
Highlights the potential of targeting angiogenic gene programming and HIF-1 to preserve coronary microvasculature in diastolic heart failure.
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Does not warrant practice change in diastolic HF; leaves clinical translation of HIF-1 activation open pending trials.
Hoenig et al. (2008) conducted a review in Hypertension, cardiac hypertrophy, and diastolic heart failure. Therapies that activate hypoxia inducible factor-1 was evaluated. Angiogenic gene programming and therapies that activate hypoxia inducible factor-1 may preserve the coronary microvasculature and maintain cardiac diastolic function in diastolic heart failure.
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