Key result
Levothyroxine therapy resolved mucosal bleeding and symptoms of hypothyroidism in a 42-year-old male with acquired von Willebrand Disease and severe hypothyroidism.
Why the study?
Does levothyroxine therapy resolve bleeding symptoms in a patient with acquired von Willebrand Disease and underlying hypothyroidism?
Case Report (n=1)
Does levothyroxine therapy resolve bleeding symptoms in a patient with acquired von Willebrand Disease and underlying hypothyroidism?
Levothyroxine therapy can resolve bleeding symptoms in patients presenting with acquired von Willebrand Disease secondary to severe hypothyroidism.
Severe hypothyroidism may underlie acquired vWD; this case leaves the association hypothesis-generating.
We describe a case of a 42-year-old male, with a 5-year history of recurrent gum bleeding, easy bruising, and chronic fatigue who presented for management of possible bleeding complications prior to a planned dental procedure. After extensive work-up, the patient was diagnosed with acquired von Willebrand Disease and underlying hypothyroidism with a thyrotropin (TSH) of 321 mIU/L (0.35-5.5) and total thyroxine (T(4)) of less than 1 microg/dL (4.5-12.5). He was started on levothyroxine and therapy and when compliant with treatment, the mucosal bleeding and symptoms of hypothyroidism were resolved. A subsequent TSH and total T(4) samples were drawn and found to be 6.3 mIU/L and 4.1 microg/dL, respectively.
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Soni et al. (2005) conducted a case report in Hypothyroidism and acquired von Willebrand Disease (n=1). Levothyroxine was evaluated on Resolution of mucosal bleeding and symptoms of hypothyroidism. Levothyroxine therapy resolved mucosal bleeding and symptoms of hypothyroidism in a 42-year-old male with acquired von Willebrand Disease and severe hypothyroidism.
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