Key result
The TC genotype of the CYP11B2 gene was the most prevalent among both hypertensive and normotensive men, with no significant difference in genotype distribution between the groups.
Why the study?
The study aimed to investigate the importance of aldosterone synthase gene (CYP11B2) polymorphism in the pathogenesis, clinic, and myocardial remodeling of hypertension.
Observational (n=150)
No
p-value: p=0.91
The TC polymorphism of the CYP11B2 gene is highly prevalent among hypertensive males in the Podillia region of Ukraine, consistent with broader European populations.
CYP11B2 variants may associate with hypertensive remodeling; leaves open prospective validation before any clinical application.
Aldosterone synthase gene is one of the candidate genes responsible for the effects of aldosterone. In particular, there are some evidences concerning the influence of this gene on the myocardial remodeling in hypertension. The analysis and summary of the results of published researches devoted to the study of aldosterone synthase gene (CYP11B2) polymorphism and its importance in the processes of hypertensive myocardial remodeling are presented in the article. Pub Med and EMBASE databases were used. The results of the study of CYP11B2 polymorphism within the framework of the research work at the Department of Internal Medicine of Medical Faculty №2 are presented in the article. The aim of the study is to study the importance of polymorphism of aldosterone synthase gene in the pathogenesis and clinic of hypertension. It has been shown that among both, hypertensive and males, residents of Podillia region of Ukraine, the overwhelming majority were carriers of TC polymorphism of CYP11B2 gene. These data are in the agreement with the previous studies in the European population.
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Lozinska et al. (2019) conducted an observational in Essential hypertension (n=150). CYP11B2 gene polymorphism vs. Normotensive controls was evaluated on Difference in CYP11B2 genotype distribution (CC, TC, TT) between stage I hypertension patients and controls (p=0.91). The TC genotype of the CYP11B2 gene was the most prevalent among both hypertensive and normotensive men, with no significant difference in genotype distribution between the groups.
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