Key result
CYP11B2 -344C allele is linked to increased LV size, impaired baroreflex sensitivity, and MI risk.
Why the study?
The effects of the aldosterone synthase (CYP11B2) -344C/T polymorphism on cardiovascular function and risk factors are not fully understood.
Is the aldosterone synthase (CYP11B2) -344C allele associated with adverse cardiovascular phenotypes and outcomes?
Is the aldosterone synthase (CYP11B2) -344C allele associated with adverse cardiovascular phenotypes and outcomes?
The CYP11B2 -344C allele may serve as a genetic marker for increased cardiovascular risk, including adverse left ventricular remodeling and myocardial infarction.
-344 CC genotype associated with higher MACE risk in hypertension; hypothesis-generating for genetic stratification, requires validation before clinical use.
In addition to regulating renal sodium resorption and, thus, intravascular volume, aldosterone may have direct effects on the cardiovascular system. We previously identified a polymorphism (-344C/T) in the promoter of the aldosterone synthase (CYP11B2) gene that affects binding of the SF-1 transcription factor and thus might influence gene expression. We found that, whereas this polymorphism has inconsistent associations with levels of aldosterone secretion and blood pressure, the -344C allele is strongly associated with increased left ventricular size and decreased baroreflex sensitivity in healthy individuals. These physiological parameters are cardiovascular risk factors. Indeed, preliminary studies suggest that the -344C allele is also associated with increased risk of myocardial infarction in high risk dyslipidemic males.
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White et al. (1998) conducted a review in Healthy individuals and high-risk dyslipidemic males. -344C allele of the aldosterone synthase (CYP11B2) gene was evaluated on Left ventricular size, baroreflex sensitivity, and myocardial infarction. The -344C allele of the aldosterone synthase (CYP11B2) gene is associated with increased left ventricular size, decreased baroreflex sensitivity, and increased risk of myocardial infarction.
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