Key result
The CYP11B2 −344C/T polymorphism showed no overall association with LVH, but the TT genotype was associated with higher left ventricular posterior wall thickness in northern Han Chinese (P=0.04).
Why the study?
Is the aldosterone synthase gene (CYP11B2) −344C/T polymorphism associated with left ventricular hypertrophy in Chinese Han?
Meta-Analysis (n=3,104)
Is the aldosterone synthase gene (CYP11B2) −344C/T polymorphism associated with left ventricular hypertrophy in Chinese Han?
Mean Difference: 0.09 (95% CI 0–0.18)
p-value: p=0.04
The TT genotype of the CYP11B2 −344C/T polymorphism may be associated with a higher risk of developing left ventricular hypertrophy in northern Han Chinese, despite no overall association in the broader Chinese Han population.
TT genotype may elevate LVH risk in northern Han Chinese; leaves open causal confirmation and screening utility.
No consensus view has been published on the relationship between the aldosterone synthase gene (CYP11B2) −344C/T polymorphism and left ventricular hypertrophy (LVH) in Chinese Han. We undertook a meta-analysis to investigate the potential association of this polymorphism and left ventricular structure-related phenotypes, including left ventricular mass (LVM), left ventricular mass index (LVMI), left ventricular end systolic diameter (LVESD), left ventricular end diastolic dimension (LVEDD), left ventricular posterior wall thickness (LVPWT), and interventricular septal wall thickness (IVS). Studies in English and Chinese were found based on a systematic search of Medline, Embase, CNKI, and Wanfang databases. The dominant model (TT vs. TC+CC) and homozygote model (TT vs. CC) were selected to examine the association between the −344C/T polymorphism and LVH. The random-effects model was used to pool data. From a total of 3104 participants, despite the investigation of six echocardiographic indicators, we found no significant association between the −344C/T variant and LVH in the whole group and the subgroup analyses by blood pressure. However, in the subgroup of northern Han Chinese, TT genotype had higher LVPWT than CC genotype and TC genotype (pheterogeneity = 0.4, pvalue = 0.04, 95% CI 0.09 (0.00, 0.18)). In addition, no evidence of publication bias was observed. In conclusion, our meta-analysis indicated that subjects with TT genotype might have higher risk of developing LVH in northern Han Chinese.
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Yin et al. (2017) conducted a meta-analysis in Left ventricular hypertrophy (LVH) (n=3,104). CYP11B2 −344C/T polymorphism (TT genotype) vs. TC+CC or CC genotype was evaluated on Left ventricular hypertrophy and structure-related phenotypes (including LVPWT) (0.09, 95% CI 0.00, 0.18, p=0.04). The CYP11B2 −344C/T polymorphism showed no overall association with LVH, but the TT genotype was associated with higher left ventricular posterior wall thickness in northern Han Chinese (P=0.04).
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