Key result
The TT genotype of the T-344C aldosterone synthase polymorphism was not significantly associated with left ventricular mass index in young normotensive men (92 vs 86 vs 84 g/m, P=0.20).
Why the study?
Is the TT genotype of the T-344C polymorphism of aldosterone synthase associated with increased left ventricular mass index and plasma renin activity in young normotensive men?
Population
113 normotensive mid-European Caucasian men aged 18-40 years (mean 27 +/- 5 years)
Comparison
TT genotype of the T-344C polymorphism of the… vs TC and CC genotypes of the T-344C polymorphism
Design
Cross-sectional
Authors
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No overall LVMI association in young normotensive men; leaves open renin-mediated effects in high-renin subgroups.
Cross-Sectional (n=113)
Is the TT genotype of the T-344C polymorphism of aldosterone synthase associated with increased left ventricular mass index and plasma renin activity in young normotensive men?
Absolute Event Rate: 92% vs 86%
p-value: p=0.20
The TT genotype of the aldosterone synthase T-344C polymorphism is associated with higher plasma renin activity and, in high-renin individuals, increased left ventricular mass index in young normotensive men.
Heller et al. (2004) conducted a cross-sectional in Normotension (n=113). T-344C polymorphism of aldosterone synthase (TT genotype) vs. TC and CC genotypes was evaluated on Left ventricular mass index (LVMI) (p=0.20). The TT genotype of the T-344C aldosterone synthase polymorphism was not significantly associated with left ventricular mass index in young normotensive men (92 vs 86 vs 84 g/m, P=0.20).
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