Key result
The CYP11B2 -344C/T polymorphism was not significantly associated with plasma aldosterone concentration, blood pressure, plasma glucose, or left ventricular mass in any ethnicity.
Why the study?
Does the aldosterone synthase gene (CYP11B2) promoter polymorphism [-344C/T] associate with cardiovascular phenotypes such as blood pressure and LV mass in a multiethnic population?
Cohort (n=3,452)
Does the aldosterone synthase gene (CYP11B2) promoter polymorphism [-344C/T] associate with cardiovascular phenotypes such as blood pressure and LV mass in a multiethnic population?
The CYP11B2 -344C/T polymorphism is not associated with plasma aldosterone concentration, blood pressure, or LV mass in a large multiethnic cohort, failing to replicate previous positive associations.
Answers are grounded in this paper and cite their sources.
No association of CYP11B2 -344C/T with PAC or BP in multiethnic adults; leaves open variant's role in hypertension.
BACKGROUND: A single-nucleotide polymorphism in the aldosterone synthase gene (CYP11B2) promoter [-344C/T, rs1799998] has been reported to associate with cardiovascular phenotypes. METHODS: The Dallas Heart Study is a large, multiethnic cohort with a high prevalence of hypertension. We genotyped 3452 Dallas Heart Study participants for -344C/T. Generalized linear models were used to assess whether variation at -344C/T associated with plasma aldosterone concentration (PAC), systolic and diastolic blood pressure (SBP and DBP), plasma glucose (in persons with no diabetes), HOMA IR (Homeostasis Model Assessment as an Index of Insulin Resistance), and left ventricular (LV) mass indexed to height. Systolic blood pressure and DBP were significantly higher in blacks compared with whites (P < 0.001 for SBP and for DBP) and Hispanics (P < 0.001 for SBP and for DBP). Log-transformed body mass index was also significantly higher in blacks compared with whites (P < 0.001), but not Hispanics (P = 0.10). Log-transformed PAC was higher in whites compared with blacks (P < 0.001), but did not differ significantly in whites compared with Hispanics (P = 0.73). In univariate and multivariable analysis, -344C/T was not significantly associated with PAC within any ethnicity. In univariate and multivariable analysis, -344C/T was not associated with SBP or DBP within any ethnicity. After adjustment for multiple testing, univariate and multivariable analyses revealed no association between -344C/T and plasma glucose in patients with no diabetes, HOMA IR, or LV mass indexed to height. CONCLUSIONS: We were unable to reproduce previously reported associations between -344C/T and PAC, blood pressure, plasma glucose, or LV mass. Methodological differences might explain the differences between our findings and those previously reported.
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Byrd et al. (2015) conducted a cohort in Cardiovascular phenotypes (n=3,452). CYP11B2 promoter polymorphism (-344C/T) was evaluated on Plasma aldosterone concentration, blood pressure, plasma glucose, HOMA IR, and left ventricular mass. The CYP11B2 -344C/T polymorphism was not significantly associated with plasma aldosterone concentration, blood pressure, plasma glucose, or left ventricular mass in any ethnicity.
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