Key result
A dual Cre and EGFP knock-in mouse line in the Myocardin locus successfully marked early cardiac and smooth muscle lineages, providing a unique tool for studying cardiovascular development.
Population
Dual Cre and enhanced green fluorescent protein (EGFP) knock-in mouse line in the Myocardin locus (Myocd(KI))
Design
Preclinical
Authors
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New genetic tool for cardiac lineage tracing; extends developmental models but leaves human translation open.
The generation of the Myocd(KI) mouse line provides a novel tool for studying cardiovascular development and lineage-specific gene manipulation.
Espinoza‐Lewis et al. (2014) studied Cardiovascular development. Myocd(KI) allele (dual Cre and EGFP knock-in) was evaluated. A dual Cre and EGFP knock-in mouse line in the Myocardin locus successfully marked early cardiac and smooth muscle lineages, providing a unique tool for studying cardiovascular development.
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