Population
Wild-type and Nkx2.5-null mouse embryos, neonatal rat and mouse cardiac myocytes, P19CL6 teratocarcinoma…
Comparison
Genetic manipulation including Nkx2.5 knockout… vs Wild-type mice, empty vector controls, and…
Design
Preclinical
Authors
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No immediate clinical implications from this animal model; extends Nkx2.5-myocardin regulation in cardiomyogenesis while leaving human relevance open.
Myocardin expression is directly regulated by the cardiac transcription factor Nkx2.5 and is essential for early cardiomyogenesis.
Ueyama et al. (2003) studied this question.
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