Key result
The proposed pacemaking variants of the Aliev-Panfilov and Corrado cell models successfully reproduced the nonlinear dynamic features of isolated cells and coupled pacemaker-excitable systems.
Why the study?
Simplified nonlinear models contain few variables and parameters to facilitate nonlinear analysis and reduce computational load, prompting investigation of pacemaking variants of two-variable excitable cell models.
Simplified pacemaking variants of the Aliev-Panfilov and Corrado cell models can effectively simulate complex tissue dynamics like the sinoatrial node, reducing computational load for physiological modeling.
Pacemaking variants enable efficient multi-organ simulations; leaves open quantitative validation before clinical modeling use.
Simplified nonlinear models of biological cells are widely used in computational electrophysiology. The models reproduce qualitatively many of the characteristics of various organs, such as the heart, brain, and intestine. In contrast to complex cellular ion-channel models, the simplified models usually contain a small number of variables and parameters, which facilitates nonlinear analysis and reduces computational load. In this paper, we consider pacemaking variants of the Aliev-Panfilov and Corrado two-variable excitable cell models. We conducted a numerical simulation study of these models and investigated the main nonlinear dynamic features of both isolated cells and 1D coupled pacemaker-excitable systems. Simulations of the 2D sinoatrial node and 3D intestine tissue as application examples of combined pacemaker-excitable systems demonstrated results similar to obtained previously. The uniform formulation for the conventional excitable cell models and proposed pacemaker models allows a convenient and easy implementation for the construction of personalized physiological models, inverse tissue modeling, and development of real-time simulation systems for various organs that contain both pacemaker and excitable cells.
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Ryzhii et al. (2021) studied Cardiac and intestinal electrophysiology. Pacemaking variants of Aliev-Panfilov and Corrado cell models vs. Conventional excitable cell models was evaluated on Nonlinear dynamic features and synchronization behavior. The proposed pacemaking variants of the Aliev-Panfilov and Corrado cell models successfully reproduced the nonlinear dynamic features of isolated cells and coupled pacemaker-excitable systems.
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