Key result
MK-801 treatment suppressed peri-infarct depolarizations and resulted in the smallest infarction sizes in cats with focal cerebral ischemia.
In a cat model of focal cerebral ischemia, recurrent peri-infarct depolarizations lead to progressive breakdown of ion homeostasis and contribute to infarct growth, a process suppressed by the NMDA antagonist MK-801.
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Hypothesis-generating for PID-calcium dynamics in gyrencephalic ischemia; human relevance and therapeutic targeting require validation.
Ohta et al. (2001) studied focal cerebral ischemia (n=22). MK-801 vs. vehicle was evaluated on Occurrence of peri-infarct depolarizations and infarction size. MK-801 treatment suppressed peri-infarct depolarizations and resulted in the smallest infarction sizes in cats with focal cerebral ischemia.
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