Key result
Labetalol and methyldopa produced similar reductions in lying (23/15 vs 28/15 mmHg) and standing (29/15 vs 29/14 mmHg) blood pressures in patients with essential hypertension.
Why the study?
Does labetalol reduce blood pressure similarly to methyldopa in patients with essential hypertension?
Population
20 patients with essential hypertension
Comparison
Labetalol (dose-titrated) vs Methyldopa (dose-titrated)
Design
RCT, double-blind
Authors
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Comparable BP control may allow individualized selection; small Level 3 trial leaves open modern comparative outcomes.
RCT (n=20)
Double-blind
cross-over
Does labetalol reduce blood pressure similarly to methyldopa in patients with essential hypertension?
Labetalol and methyldopa demonstrate similar antihypertensive efficacy in reducing both lying and standing blood pressures in patients with essential hypertension.
Sanders et al. (1979) conducted an RCT in essential hypertension (n=20). Labetalol vs. Methyldopa was evaluated on Lying and standing blood pressure. Labetalol and methyldopa produced similar reductions in lying (23/15 vs 28/15 mmHg) and standing (29/15 vs 29/14 mmHg) blood pressures in patients with essential hypertension.
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