Key result
Treatment with oral omadacycline resulted in complete resolution of left lower extremity cellulitis in a 68-year-old man with multiple comorbidities, enabling early hospital discharge.
Why the study?
Pathogen identification in cellulitis is often clinically impossible, complicating antibiotic selection in patients with multiple comorbidities, risk factors for recurrence, and a need for prompt oral discharge therapy.
Case Report (n=1)
Omadacycline may be a useful oral antibiotic option for outpatient management of suspected cellulitis requiring MRSA coverage in patients with multiple comorbidities.
May support early discharge with oral omadacycline in select comorbid cellulitis; hypothesis-generating and requires prospective trials.
In cases of cellulitis, identification of a specific pathogen is often not possible on clinical grounds, and in our institution the recommended practice for empiric treatment of skin infections is to cover for the usual pathogens, such as Staphylococcus aureus and Streptococcus pyogenes. This article describes the management of a 68-year-old man in whom the choice of appropriate antibiotic treatment for suspected cellulitis was complicated by many factors, including several known risk factors for recurrent cellulitis, multiple comorbid conditions, and the patient’s wish to leave hospital as soon as possible. Given this patient’s clinical syndrome, coverage for methicillin-resistant S. aureus was part of the treatment decision, and to enable a prompt discharge, an effective oral treatment was needed for him to take at home. These and other considerations that guided the selection of omadacycline as appropriate antibiotic therapy for this patient are discussed.
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Hameed Ali (2023) conducted a case report in Cellulitis (n=1). Omadacycline was evaluated on Resolution of cellulitis. Treatment with oral omadacycline resulted in complete resolution of left lower extremity cellulitis in a 68-year-old man with multiple comorbidities, enabling early hospital discharge.
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